KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B5
All Species:
27.27
Human Site:
S433
Identified Species:
50
UniProt:
Q13144
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13144
NP_003898.2
721
80380
S433
K
P
R
S
V
L
T
S
Q
V
V
V
G
P
N
Chimpanzee
Pan troglodytes
XP_001139517
721
80405
S433
K
P
R
C
V
L
T
S
Q
V
V
V
G
P
N
Rhesus Macaque
Macaca mulatta
XP_001104122
721
80584
S433
K
P
R
C
V
L
T
S
Q
V
V
V
G
P
N
Dog
Lupus familis
XP_545227
721
80416
S433
K
P
R
C
V
L
T
S
Q
V
V
V
G
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHW4
717
80068
S429
K
P
Y
C
V
L
T
S
Q
V
V
V
G
P
D
Rat
Rattus norvegicus
Q64350
716
80188
S428
K
P
H
C
V
L
T
S
Q
V
V
V
G
P
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506973
657
73984
D401
E
D
D
D
Q
F
S
D
D
S
G
A
D
K
E
Chicken
Gallus gallus
XP_422755
716
81293
S419
K
P
H
C
V
L
S
S
Q
V
V
V
G
P
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107069
703
79791
Y415
N
E
Q
C
V
L
A
Y
N
V
V
V
G
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784928
1190
133261
F894
K
N
G
C
V
L
S
F
G
V
K
V
G
P
H
Poplar Tree
Populus trichocarpa
XP_002328528
718
80680
F414
E
P
G
V
V
L
S
F
K
V
V
I
G
Q
Q
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_181042
730
81845
F420
Q
P
G
V
V
L
S
F
N
V
V
V
G
R
D
Baker's Yeast
Sacchar. cerevisiae
P32501
712
81143
F416
N
D
G
C
I
I
G
F
N
V
K
I
D
D
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.3
93.1
N.A.
88.3
88.3
N.A.
77.2
73.2
N.A.
62.9
N.A.
N.A.
N.A.
N.A.
27.2
Protein Similarity:
100
99.8
99
96.2
N.A.
93.4
93.9
N.A.
83.7
85.3
N.A.
78.5
N.A.
N.A.
N.A.
N.A.
40
P-Site Identity:
100
93.3
93.3
86.6
N.A.
80
80
N.A.
0
73.3
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
86.6
86.6
N.A.
13.3
86.6
N.A.
60
N.A.
N.A.
N.A.
N.A.
60
Percent
Protein Identity:
33.8
N.A.
N.A.
32.7
28.8
N.A.
Protein Similarity:
55.2
N.A.
N.A.
53.2
50
N.A.
P-Site Identity:
40
N.A.
N.A.
46.6
13.3
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
70
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
8
8
0
0
0
8
8
0
0
0
16
8
47
% D
% Glu:
16
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
8
0
31
0
0
0
0
0
0
0
% F
% Gly:
0
0
31
0
0
0
8
0
8
0
8
0
85
0
0
% G
% His:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
8
8
0
0
0
0
0
16
0
0
0
% I
% Lys:
62
0
0
0
0
0
0
0
8
0
16
0
0
8
0
% K
% Leu:
0
0
0
0
0
85
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
8
0
0
0
0
0
0
24
0
0
0
0
0
31
% N
% Pro:
0
70
0
0
0
0
0
0
0
0
0
0
0
70
0
% P
% Gln:
8
0
8
0
8
0
0
0
54
0
0
0
0
8
8
% Q
% Arg:
0
0
31
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
8
0
0
39
54
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
16
85
0
0
0
0
93
77
77
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _